Muhammad had her first taste of international success while she was still in high school when she won the 2007 IAAF World Youth title. She went on to enjoy a successful career at USC where she was a 4 time NCAA Outdoor All-American. Muhammad had a breakthrough year in 2013, where she lowered her PR by an impressive two and half seconds. Muhammad won her first senior national title to secure her spot at the World Championships in Moscow. In 2016 Muhammad won another outdoor champion earning her spot in the 2016 Olympic team. At the games she won the women's 400 meter hurdles making her the first American women in history to ever do so. She is currently coached by Lawrence Johnson.